藥物交互作用
Bacillus calmette-guerin substrain tice + Isoniazid
嚴重程度: 嚴重
Bacillus calmette-guerin substrain tice and Isoniazid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
BCG is a live attenuated Mycobacterium bovis, and isoniazid is active against mycobacteria, so it can reduce the viability and effect of intravesical BCG. This can lower the efficacy of bladder cancer immunotherapy.
用白話說明這項交互作用的意義
Bacillus calmette-guerin substrain tice and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacillus calmette-guerin substrain tice belongs to Oncology; Isoniazid belongs to Anti Bacterial.
為什麼會發生
Antimycobacterial activity of isoniazid against the live BCG organisms reduces their viability and therefore immunotherapeutic activity.
處置方式
Avoid giving antituberculosis drugs during intravesical BCG therapy unless needed to treat BCG infection. Use alternative non-antimycobacterial agents for local irritative symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Isoniazid 的其他交互作用
常見問題
Can I take Bacillus calmette-guerin substrain tice with Isoniazid?
MediHelp rates the interaction as major. Bacillus calmette-guerin substrain tice and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. BCG is a live attenuated Mycobacterium bovis, and isoniazid is active against mycobacteria, so it can reduce the viability and effect of intravesical BCG. This can lower the efficacy of bladder cancer immunotherapy.
How serious is the interaction between Bacillus calmette-guerin substrain tice and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving antituberculosis drugs during intravesical BCG therapy unless needed to treat BCG infection. Use alternative non-antimycobacterial agents for local irritative symptoms.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Benzhydrocodone / acetaminophen, Carbamazepine, Didanosine. The full list is on the Isoniazid page.
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