藥物交互作用
Dihydroergotamine intranasal + Isoniazid
嚴重程度: 嚴重
Dihydroergotamine intranasal and Isoniazid: major interaction.
最後更新
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摘要
Intranasal dihydroergotamine is systemically absorbed and its clearance depends on CYP3A4. Isoniazid may increase exposure and the risk of ergot-related vasospasm and ischemia.
用白話說明這項交互作用的意義
Dihydroergotamine intranasal and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Inhibition of CYP3A4 metabolism of dihydroergotamine.
處置方式
Avoid if possible and use a non-ergot alternative during isoniazid therapy. If used, monitor for peripheral ischemia and stop at the first signs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Isoniazid 的其他交互作用
常見問題
Can I take Dihydroergotamine intranasal with Isoniazid?
MediHelp rates the interaction as major. Dihydroergotamine intranasal and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intranasal dihydroergotamine is systemically absorbed and its clearance depends on CYP3A4. Isoniazid may increase exposure and the risk of ergot-related vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use a non-ergot alternative during isoniazid therapy. If used, monitor for peripheral ischemia and stop at the first signs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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