藥物交互作用
Dihydroergotamine + Isoniazid
嚴重程度: 嚴重
Dihydroergotamine and Isoniazid: major interaction.
最後更新
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摘要
Dihydroergotamine levels rise when CYP3A4 is inhibited, risking ergotism with severe peripheral vasospasm and ischemia. Isoniazid is a weaker CYP3A4 inhibitor than agents named in the labeling contraindication, but the toxicity is serious.
用白話說明這項交互作用的意義
Dihydroergotamine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP3A4 metabolism of dihydroergotamine.
處置方式
Avoid if possible and choose an alternative migraine therapy during isoniazid treatment. If used, monitor for numbness, coldness, or pain in the extremities and stop at the first signs of ischemia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Isoniazid 的其他交互作用
Dihydroergotamine 的其他交互作用
常見問題
Can I take Dihydroergotamine with Isoniazid?
MediHelp rates the interaction as major. Dihydroergotamine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine levels rise when CYP3A4 is inhibited, risking ergotism with severe peripheral vasospasm and ischemia. Isoniazid is a weaker CYP3A4 inhibitor than agents named in the labeling contraindication, but the toxicity is serious.
How serious is the interaction between Dihydroergotamine and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative migraine therapy during isoniazid treatment. If used, monitor for numbness, coldness, or pain in the extremities and stop at the first signs of ischemia.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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