藥物交互作用
Baricitinib + Penicillin g procaine-penicillin g
嚴重程度: 中度
Baricitinib and Penicillin g procaine-penicillin g: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
用白話說明這項交互作用的意義
Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Penicillin g procaine-penicillin g belongs to Anti Bacterial.
為什麼會發生
Inhibition of renal OAT3-mediated tubular secretion of baricitinib by penicillin G reduces its elimination.
處置方式
Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Penicillin g procaine-penicillin g 的其他交互作用
- Amifampridine + Penicillin g procaine-penicillin g 中度
- Cholera vaccine + Penicillin g procaine-penicillin g 中度
- Microbiota + Penicillin g procaine-penicillin g 中度
- Omadacycline + Penicillin g procaine-penicillin g 中度
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid 中度
- Penicillin g procaine-penicillin g + Vadadustat 中度
Baricitinib 的其他交互作用
常見問題
Can I take Baricitinib with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
How serious is the interaction between Baricitinib and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Cholera vaccine, Microbiota. The full list is on the Penicillin g procaine-penicillin g page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
