藥物交互作用
Bcg vaccine live + Cilastatin-imipenem
嚴重程度: 中度
Bcg vaccine live and Cilastatin-imipenem: moderate interaction.
最後更新
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摘要
Live BCG relies on viable bacteria to induce immunity, and antibacterial agents active against mycobacteria or related organisms may reduce vaccine viability. Imipenem has some activity against BCG strains, so the immune response could be blunted.
用白話說明這項交互作用的意義
Bcg vaccine live and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Antibacterial activity may reduce the viability of the live attenuated organism.
處置方式
Delay BCG vaccination until the antibiotic course is complete, where this is clinically feasible. Repeat vaccination or assess response if the vaccine was given during therapy.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cilastatin-imipenem 的其他交互作用
常見問題
Can I take Bcg vaccine live with Cilastatin-imipenem?
MediHelp rates the interaction as moderate. Bcg vaccine live and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live BCG relies on viable bacteria to induce immunity, and antibacterial agents active against mycobacteria or related organisms may reduce vaccine viability. Imipenem has some activity against BCG strains, so the immune response could be blunted.
How serious is the interaction between Bcg vaccine live and Cilastatin-imipenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay BCG vaccination until the antibiotic course is complete, where this is clinically feasible. Repeat vaccination or assess response if the vaccine was given during therapy.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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