藥物交互作用
Cholera vaccine + Cilastatin-imipenem
嚴重程度: 中度
Cholera vaccine and Cilastatin-imipenem: moderate interaction.
最後更新
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摘要
Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
用白話說明這項交互作用的意義
Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
處置方式
Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cilastatin-imipenem 的其他交互作用
常見問題
Can I take Cholera vaccine with Cilastatin-imipenem?
MediHelp rates the interaction as moderate. Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
How serious is the interaction between Cholera vaccine and Cilastatin-imipenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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