藥物交互作用
Belladonna and opium + Chlorpheniramine
嚴重程度: 嚴重
Belladonna and opium and Chlorpheniramine: major interaction.
最後更新 來源: US FDA label
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摘要
The opium component adds CNS and respiratory depression to the sedation of chlorpheniramine, and belladonna adds anticholinergic burden. The combination can cause marked drowsiness, constipation, urinary retention and confusion.
用白話說明這項交互作用的意義
Belladonna and opium and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive opioid CNS and respiratory depression plus additive anticholinergic effects.
處置方式
Avoid if possible; otherwise use the lowest doses and monitor sedation, respiration and anticholinergic effects. Use a non-sedating antihistamine instead.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Chlorpheniramine 的其他交互作用
- Benzhydrocodone / acetaminophen + Chlorpheniramine 嚴重
- Brexanolone + Chlorpheniramine 嚴重
- Buprenorphine long-acting + Chlorpheniramine 嚴重
- Buprenorphine subdermal implant + Chlorpheniramine 嚴重
- Buprenorphine transdermal + Chlorpheniramine 嚴重
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine 嚴重
常見問題
Can I take Belladonna and opium with Chlorpheniramine?
MediHelp rates the interaction as major. Belladonna and opium and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component adds CNS and respiratory depression to the sedation of chlorpheniramine, and belladonna adds anticholinergic burden. The combination can cause marked drowsiness, constipation, urinary retention and confusion.
How serious is the interaction between Belladonna and opium and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses and monitor sedation, respiration and anticholinergic effects. Use a non-sedating antihistamine instead.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine long-acting. The full list is on the Chlorpheniramine page.
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