藥物交互作用
Brexanolone + Chlorpheniramine
嚴重程度: 嚴重
Brexanolone and Chlorpheniramine: major interaction.
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摘要
Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
用白話說明這項交互作用的意義
Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS depression via GABA-A modulation and H1 antagonism.
處置方式
Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlorpheniramine 的其他交互作用
- Belladonna and opium + Chlorpheniramine 嚴重
- Benzhydrocodone / acetaminophen + Chlorpheniramine 嚴重
- Buprenorphine long-acting + Chlorpheniramine 嚴重
- Buprenorphine subdermal implant + Chlorpheniramine 嚴重
- Buprenorphine transdermal + Chlorpheniramine 嚴重
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine 嚴重
常見問題
Can I take Brexanolone with Chlorpheniramine?
MediHelp rates the interaction as major. Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
How serious is the interaction between Brexanolone and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Buprenorphine long-acting. The full list is on the Chlorpheniramine page.
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