藥物交互作用
Buprenorphine long-acting + Chlorpheniramine
嚴重程度: 嚴重
Buprenorphine long-acting and Chlorpheniramine: major interaction.
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摘要
Chlorpheniramine adds sedation to buprenorphine, increasing the risk of drowsiness and respiratory depression. The long-acting injection depot cannot be quickly removed.
用白話說明這項交互作用的意義
Buprenorphine long-acting and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS depression from an opioid and a sedating antihistamine.
處置方式
Prefer a non-sedating antihistamine. If combined, limit dose and duration of chlorpheniramine and monitor for sedation and respiratory depression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlorpheniramine 的其他交互作用
常見問題
Can I take Buprenorphine long-acting with Chlorpheniramine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpheniramine adds sedation to buprenorphine, increasing the risk of drowsiness and respiratory depression. The long-acting injection depot cannot be quickly removed.
How serious is the interaction between Buprenorphine long-acting and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. If combined, limit dose and duration of chlorpheniramine and monitor for sedation and respiratory depression.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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