藥物交互作用
Bendamustine + Etrasimod
嚴重程度: 嚴重
Bendamustine and Etrasimod: major interaction.
最後更新
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摘要
Etrasimod lowers circulating lymphocytes through S1P receptor modulation, and bendamustine is lymphotoxic and myelosuppressive. Combined use may add to immunosuppression and infection risk, and it has not been studied.
用白話說明這項交互作用的意義
Bendamustine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bendamustine belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
為什麼會發生
Additive immunosuppression from S1P-mediated lymphocyte sequestration and bendamustine myelosuppression.
處置方式
Avoid combining where possible, allowing for prolonged immune effects after etrasimod is stopped. If used together, monitor blood counts and infections.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bendamustine 的其他交互作用
Etrasimod 的其他交互作用
常見問題
Can I take Bendamustine with Etrasimod?
MediHelp rates the interaction as major. Bendamustine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes through S1P receptor modulation, and bendamustine is lymphotoxic and myelosuppressive. Combined use may add to immunosuppression and infection risk, and it has not been studied.
How serious is the interaction between Bendamustine and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, allowing for prolonged immune effects after etrasimod is stopped. If used together, monitor blood counts and infections.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
