藥物交互作用
Benzhydrocodone / acetaminophen + Chlordiazepoxide
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Chlordiazepoxide: major interaction.
最後更新
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摘要
Combining a benzodiazepine with an opioid such as benzhydrocodone can cause profound sedation, respiratory depression, coma and death. This is a boxed warning class effect for opioids with benzodiazepines.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression from opioid receptor agonism and GABA-A potentiation.
處置方式
Reserve concomitant use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression and consider naloxone availability.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Chlordiazepoxide?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid such as benzhydrocodone can cause profound sedation, respiratory depression, coma and death. This is a boxed warning class effect for opioids with benzodiazepines.
How serious is the interaction between Benzhydrocodone / acetaminophen and Chlordiazepoxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concomitant use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression and consider naloxone availability.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
