藥物交互作用
Amobarbital + Chlordiazepoxide
嚴重程度: 嚴重
Amobarbital and Chlordiazepoxide: major interaction.
最後更新
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摘要
Barbiturates and benzodiazepines together produce marked additive sedation and respiratory depression. Amobarbital also induces hepatic enzymes and may lower chlordiazepoxide exposure over time, making the net effect unpredictable.
用白話說明這項交互作用的意義
Amobarbital and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Chlordiazepoxide belongs to Central Nervous System.
為什麼會發生
Additive CNS depression at GABA-A receptors plus CYP3A4 induction by amobarbital, which increases chlordiazepoxide metabolism.
處置方式
Avoid combining where possible; if needed, use the lowest doses and monitor respiratory rate and level of consciousness. Reassess benzodiazepine dosing when the barbiturate is started or stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Chlordiazepoxide?
MediHelp rates the interaction as major. Amobarbital and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce marked additive sedation and respiratory depression. Amobarbital also induces hepatic enzymes and may lower chlordiazepoxide exposure over time, making the net effect unpredictable.
How serious is the interaction between Amobarbital and Chlordiazepoxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if needed, use the lowest doses and monitor respiratory rate and level of consciousness. Reassess benzodiazepine dosing when the barbiturate is started or stopped.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Atazanavir. The full list is on the Chlordiazepoxide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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