藥物交互作用
Atazanavir + Chlordiazepoxide
嚴重程度: 嚴重
Atazanavir and Chlordiazepoxide: major interaction.
最後更新
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摘要
Atazanavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise chlordiazepoxide and its active metabolites. This can lead to prolonged sedation and respiratory depression.
用白話說明這項交互作用的意義
Atazanavir and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Chlordiazepoxide belongs to Central Nervous System.
為什麼會發生
Inhibition of CYP3A4-mediated chlordiazepoxide metabolism.
處置方式
Use a reduced chlordiazepoxide dose with monitoring for oversedation, or switch to lorazepam or oxazepam.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Chlordiazepoxide?
MediHelp rates the interaction as major. Atazanavir and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise chlordiazepoxide and its active metabolites. This can lead to prolonged sedation and respiratory depression.
How serious is the interaction between Atazanavir and Chlordiazepoxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced chlordiazepoxide dose with monitoring for oversedation, or switch to lorazepam or oxazepam.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
