藥物交互作用
Benzhydrocodone / acetaminophen + Oxazepam
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Oxazepam: major interaction.
最後更新
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摘要
Combining a benzodiazepine with an opioid causes additive CNS and respiratory depression. This can produce profound sedation, respiratory failure, coma, and death.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive pharmacodynamic CNS and respiratory depression via GABA-A potentiation and opioid receptor agonism.
處置方式
Reserve combined use for patients without adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Oxazepam 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Oxazepam?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid causes additive CNS and respiratory depression. This can produce profound sedation, respiratory failure, coma, and death.
How serious is the interaction between Benzhydrocodone / acetaminophen and Oxazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients without adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
