藥物交互作用
Amobarbital + Oxazepam
嚴重程度: 嚴重
Amobarbital and Oxazepam: major interaction.
最後更新
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摘要
Barbiturates and benzodiazepines together produce profound additive CNS and respiratory depression. Risk includes excessive sedation, hypotension, coma and death, particularly with parenteral amobarbital.
用白話說明這項交互作用的意義
Amobarbital and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
為什麼會發生
Both enhance GABA-A receptor activity at different sites, producing additive CNS and respiratory depression.
處置方式
Avoid combining where possible; if required, reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Oxazepam 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Oxazepam?
MediHelp rates the interaction as major. Amobarbital and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce profound additive CNS and respiratory depression. Risk includes excessive sedation, hypotension, coma and death, particularly with parenteral amobarbital.
How serious is the interaction between Amobarbital and Oxazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if required, reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness closely.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
