藥物交互作用
Calcium / magnesium / potassium / sodium oxybates + Oxazepam
嚴重程度: 禁忌併用
Calcium / magnesium / potassium / sodium oxybates and Oxazepam: contraindicated interaction.
最後更新
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摘要
Oxybates combined with benzodiazepines cause additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Concomitant use with sedative hypnotics is restricted in labeling.
用白話說明這項交互作用的意義
Calcium / magnesium / potassium / sodium oxybates and Oxazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive CNS depression via GABA-B agonism by oxybate and GABA-A potentiation by oxazepam.
處置方式
Avoid the combination; if a benzodiazepine is essential, consider an alternative to oxybate or stop one drug. Monitor respiratory status if unavoidable.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Oxazepam 的其他交互作用
常見問題
Can I take Calcium / magnesium / potassium / sodium oxybates with Oxazepam?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Oxazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates combined with benzodiazepines cause additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Concomitant use with sedative hypnotics is restricted in labeling.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Oxazepam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a benzodiazepine is essential, consider an alternative to oxybate or stop one drug. Monitor respiratory status if unavoidable.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Sodium oxybate, Alfentanil, Amobarbital. The full list is on the Oxazepam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
