藥物交互作用
Betaxolol + Indacaterol-glycopyrronium
嚴重程度: 嚴重
Betaxolol and Indacaterol-glycopyrronium: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Beta-blockers antagonize the bronchodilating effect of indacaterol and may provoke bronchospasm in patients with obstructive airway disease. Betaxolol is cardioselective, which lowers but does not remove this risk, and this applies to oral betaxolol or ophthalmic use with systemic absorption.
用白話說明這項交互作用的意義
Betaxolol and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Betaxolol belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
為什麼會發生
Pharmacodynamic antagonism at beta-2 adrenoceptors, with loss of cardioselectivity at higher doses.
處置方式
Avoid if possible; if a beta-blocker is required, use the lowest effective dose of a cardioselective agent and monitor lung function and symptoms. Watch for reduced bronchodilator response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Indacaterol-glycopyrronium 的其他交互作用
Betaxolol 的其他交互作用
常見問題
Can I take Betaxolol with Indacaterol-glycopyrronium?
MediHelp rates the interaction as major. Betaxolol and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Beta-blockers antagonize the bronchodilating effect of indacaterol and may provoke bronchospasm in patients with obstructive airway disease. Betaxolol is cardioselective, which lowers but does not remove this risk, and this applies to oral betaxolol or ophthalmic use with systemic absorption.
How serious is the interaction between Betaxolol and Indacaterol-glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if a beta-blocker is required, use the lowest effective dose of a cardioselective agent and monitor lung function and symptoms. Watch for reduced bronchodilator response.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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