藥物交互作用
Clomipramine + Indacaterol-glycopyrronium
嚴重程度: 嚴重
Clomipramine and Indacaterol-glycopyrronium: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. Clomipramine is also strongly anticholinergic, adding to glycopyrronium's antimuscarinic effects.
用白話說明這項交互作用的意義
Clomipramine and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
為什麼會發生
Additive QT prolongation, enhanced adrenergic cardiac effects and additive antimuscarinic activity.
處置方式
Obtain a baseline ECG and monitor QTc, heart rate and electrolytes. Watch for anticholinergic effects such as urinary retention and constipation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Indacaterol-glycopyrronium 的其他交互作用
Clomipramine 的其他交互作用
常見問題
Can I take Clomipramine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as major. Clomipramine and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. Clomipramine is also strongly anticholinergic, adding to glycopyrronium's antimuscarinic effects.
How serious is the interaction between Clomipramine and Indacaterol-glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, heart rate and electrolytes. Watch for anticholinergic effects such as urinary retention and constipation.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
