藥物交互作用
Brentuximab vedotin + Ketoconazole
嚴重程度: 中度
Brentuximab vedotin and Ketoconazole: moderate interaction.
最後更新
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摘要
Ketoconazole increases exposure to the cytotoxic component of brentuximab vedotin (MMAE). This may increase the risk of neutropenia and other toxicities.
用白話說明這項交互作用的意義
Brentuximab vedotin and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Ketoconazole belongs to Anti Fungals.
為什麼會發生
Ketoconazole inhibits CYP3A4, which metabolizes monomethyl auristatin E (MMAE).
處置方式
Monitor closely for neutropenia and other adverse reactions with blood counts, and consider dose modification or treatment delay if toxicity develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ketoconazole 的其他交互作用
Brentuximab vedotin 的其他交互作用
常見問題
Can I take Brentuximab vedotin with Ketoconazole?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole increases exposure to the cytotoxic component of brentuximab vedotin (MMAE). This may increase the risk of neutropenia and other toxicities.
How serious is the interaction between Brentuximab vedotin and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia and other adverse reactions with blood counts, and consider dose modification or treatment delay if toxicity develops.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
