藥物交互作用
Avanafil + Ketoconazole
嚴重程度: 禁忌併用
Avanafil and Ketoconazole: contraindicated interaction.
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摘要
Ketoconazole is a strong CYP3A4 inhibitor and markedly increases avanafil exposure. Hypotension, priapism and cardiovascular events are more likely.
用白話說明這項交互作用的意義
Avanafil and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Ketoconazole belongs to Anti Fungals.
為什麼會發生
Strong CYP3A4 inhibition increases avanafil exposure
處置方式
Do not use together; choose a different PDE5 inhibitor or antimicrobial.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Avanafil 的其他交互作用
Ketoconazole 的其他交互作用
常見問題
Can I take Avanafil with Ketoconazole?
MediHelp rates the interaction as contraindicated. Avanafil and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole is a strong CYP3A4 inhibitor and markedly increases avanafil exposure. Hypotension, priapism and cardiovascular events are more likely.
How serious is the interaction between Avanafil and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different PDE5 inhibitor or antimicrobial.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
