藥物交互作用
Brentuximab vedotin + Mifepristone
嚴重程度: 中度
Brentuximab vedotin and Mifepristone: moderate interaction.
最後更新
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摘要
Mifepristone inhibits CYP3A4, which metabolizes the MMAE released from brentuximab vedotin. Raised MMAE exposure may increase neutropenia and peripheral neuropathy.
用白話說明這項交互作用的意義
Brentuximab vedotin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Mifepristone belongs to Endocrine.
為什麼會發生
CYP3A4 inhibition by mifepristone reduces MMAE clearance.
處置方式
Monitor blood counts and neuropathy symptoms closely. Consider dose delay or reduction if toxicity occurs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Mifepristone 的其他交互作用
Brentuximab vedotin 的其他交互作用
常見問題
Can I take Brentuximab vedotin with Mifepristone?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, which metabolizes the MMAE released from brentuximab vedotin. Raised MMAE exposure may increase neutropenia and peripheral neuropathy.
How serious is the interaction between Brentuximab vedotin and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms closely. Consider dose delay or reduction if toxicity occurs.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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