藥物交互作用
Brexpiprazole + Buprenorphine buccal
嚴重程度: 嚴重
Brexpiprazole and Buprenorphine buccal: major interaction.
最後更新
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摘要
Using brexpiprazole with buccal buprenorphine may cause additive drowsiness and slowed breathing. Cognitive and motor impairment can also be increased.
用白話說明這項交互作用的意義
Brexpiprazole and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS depression between an opioid partial agonist and a sedating antipsychotic.
處置方式
Use only if alternatives are inadequate, keep doses low, and monitor for excessive sedation and respiratory depression, especially at initiation and after dose changes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Brexpiprazole 的其他交互作用
常見問題
Can I take Brexpiprazole with Buprenorphine buccal?
MediHelp rates the interaction as major. Brexpiprazole and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using brexpiprazole with buccal buprenorphine may cause additive drowsiness and slowed breathing. Cognitive and motor impairment can also be increased.
How serious is the interaction between Brexpiprazole and Buprenorphine buccal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, keep doses low, and monitor for excessive sedation and respiratory depression, especially at initiation and after dose changes.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
