藥物交互作用
Bumetanide + Ethacrynic acid
嚴重程度: 嚴重
Bumetanide and Ethacrynic acid: major interaction.
最後更新
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摘要
Both are loop diuretics acting at the same site, so combining them offers no real therapeutic advantage and increases the risk of excessive diuresis, electrolyte depletion and volume loss. Ototoxicity risk is also additive.
用白話說明這項交互作用的意義
Bumetanide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
為什麼會發生
Duplicate inhibition of the Na-K-2Cl cotransporter producing additive diuresis, electrolyte loss and ototoxicity.
處置方式
Avoid concurrent use of two loop diuretics; use one agent and titrate the dose. If a switch is made, such as for sulfonamide allergy, stop the first agent.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bumetanide 的其他交互作用
Ethacrynic acid 的其他交互作用
常見問題
Can I take Bumetanide with Ethacrynic acid?
MediHelp rates the interaction as major. Bumetanide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are loop diuretics acting at the same site, so combining them offers no real therapeutic advantage and increases the risk of excessive diuresis, electrolyte depletion and volume loss. Ototoxicity risk is also additive.
How serious is the interaction between Bumetanide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two loop diuretics; use one agent and titrate the dose. If a switch is made, such as for sulfonamide allergy, stop the first agent.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
