藥物交互作用
Captopril-hydrochlorothiazide + Ethacrynic acid
嚴重程度: 嚴重
Captopril-hydrochlorothiazide and Ethacrynic acid: major interaction.
最後更新
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摘要
Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces sequential nephron blockade with marked diuresis and loss of potassium, sodium and magnesium. Together with an ACE inhibitor this may cause severe hypotension and acute kidney injury, particularly in volume-depleted patients.
用白話說明這項交互作用的意義
Captopril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
為什麼會發生
Additive natriuresis and electrolyte wasting from loop and thiazide diuretics, plus ACE inhibitor reduction of glomerular filtration pressure in volume depletion.
處置方式
Monitor blood pressure, volume status, electrolytes and creatinine closely, particularly in the first days. Reduce or hold the diuretics if hypotension, hypokalemia or rising creatinine occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Captopril-hydrochlorothiazide 的其他交互作用
Ethacrynic acid 的其他交互作用
常見問題
Can I take Captopril-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces sequential nephron blockade with marked diuresis and loss of potassium, sodium and magnesium. Together with an ACE inhibitor this may cause severe hypotension and acute kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, electrolytes and creatinine closely, particularly in the first days. Reduce or hold the diuretics if hypotension, hypokalemia or rising creatinine occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
