藥物交互作用
Bumetanide + Cisplatin
嚴重程度: 嚴重
Bumetanide and Cisplatin: major interaction.
最後更新
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摘要
Both drugs can damage the inner ear, and combined use may increase the risk or severity of hearing loss and tinnitus. Loop diuretic-induced volume depletion may also worsen cisplatin nephrotoxicity.
用白話說明這項交互作用的意義
Bumetanide and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Cisplatin belongs to Oncology.
為什麼會發生
Additive ototoxicity via cochlear hair cell injury, with possible added renal toxicity from volume depletion.
處置方式
Avoid bumetanide where possible during cisplatin therapy; if needed, use the lowest dose, maintain hydration, and monitor hearing and renal function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bumetanide 的其他交互作用
Cisplatin 的其他交互作用
常見問題
Can I take Bumetanide with Cisplatin?
MediHelp rates the interaction as major. Bumetanide and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the inner ear, and combined use may increase the risk or severity of hearing loss and tinnitus. Loop diuretic-induced volume depletion may also worsen cisplatin nephrotoxicity.
How serious is the interaction between Bumetanide and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid bumetanide where possible during cisplatin therapy; if needed, use the lowest dose, maintain hydration, and monitor hearing and renal function.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
