藥物交互作用
Bupivacaine liposome + Lidocaine
嚴重程度: 嚴重
Bupivacaine liposome and Lidocaine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Non-bupivacaine local anesthetics such as lidocaine can disrupt the liposomal formulation and release free bupivacaine rapidly. This eliminates the prolonged-release profile and may increase the risk of systemic bupivacaine toxicity. Labeling advises against mixing and recommends a delay after lidocaine.
用白話說明這項交互作用的意義
Bupivacaine liposome and Lidocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Lidocaine alters the liposomal carrier, causing rapid release of unencapsulated bupivacaine.
處置方式
Do not mix the products in the same syringe. If lidocaine is used first, wait at least 20 minutes before infiltrating bupivacaine liposome.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lidocaine 的其他交互作用
常見問題
Can I take Bupivacaine liposome with Lidocaine?
MediHelp rates the interaction as major. Bupivacaine liposome and Lidocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Non-bupivacaine local anesthetics such as lidocaine can disrupt the liposomal formulation and release free bupivacaine rapidly. This eliminates the prolonged-release profile and may increase the risk of systemic bupivacaine toxicity. Labeling advises against mixing and recommends a delay after lidocaine.
How serious is the interaction between Bupivacaine liposome and Lidocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not mix the products in the same syringe. If lidocaine is used first, wait at least 20 minutes before infiltrating bupivacaine liposome.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells, Nirmatrelvir / ritonavir. The full list is on the Lidocaine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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