藥物交互作用
Lidocaine + Pimozide
嚴重程度: 嚴重
Lidocaine and Pimozide: major interaction.
最後更新
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摘要
Systemic lidocaine, such as intravenous use as an antiarrhythmic, may add to the QT-prolonging and proarrhythmic potential of pimozide. Pimozide is a high-risk QT-prolonging drug and torsades de pointes is a concern. Local anesthetic use gives minimal systemic exposure and is less relevant.
用白話說明這項交互作用的意義
Lidocaine and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lidocaine belongs to Cardiovascular; Pimozide belongs to Central Nervous System.
為什麼會發生
Additive cardiac electrophysiologic effects with pimozide-related QT prolongation.
處置方式
Avoid systemic lidocaine with pimozide if possible, or monitor ECG continuously and keep potassium and magnesium normal. Prefer minimal doses for local anesthesia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lidocaine 的其他交互作用
Pimozide 的其他交互作用
常見問題
Can I take Lidocaine with Pimozide?
MediHelp rates the interaction as major. Lidocaine and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic lidocaine, such as intravenous use as an antiarrhythmic, may add to the QT-prolonging and proarrhythmic potential of pimozide. Pimozide is a high-risk QT-prolonging drug and torsades de pointes is a concern. Local anesthetic use gives minimal systemic exposure and is less relevant.
How serious is the interaction between Lidocaine and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic lidocaine with pimozide if possible, or monitor ECG continuously and keep potassium and magnesium normal. Prefer minimal doses for local anesthesia.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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