藥物交互作用
Disopyramide + Lidocaine
嚴重程度: 嚴重
Disopyramide and Lidocaine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both are class I antiarrhythmics with negative inotropic and conduction-slowing effects. Together they may cause additive myocardial depression, conduction block, proarrhythmia or worsening heart failure, particularly with structural heart disease.
用白話說明這項交互作用的意義
Disopyramide and Lidocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Lidocaine belongs to Cardiovascular.
為什麼會發生
Additive sodium channel blockade and negative inotropy.
處置方式
Use with continuous ECG and hemodynamic monitoring, and avoid in patients with heart failure or conduction disease. Reduce doses and stop if QRS widening or hypotension occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lidocaine 的其他交互作用
Disopyramide 的其他交互作用
常見問題
Can I take Disopyramide with Lidocaine?
MediHelp rates the interaction as major. Disopyramide and Lidocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are class I antiarrhythmics with negative inotropic and conduction-slowing effects. Together they may cause additive myocardial depression, conduction block, proarrhythmia or worsening heart failure, particularly with structural heart disease.
How serious is the interaction between Disopyramide and Lidocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with continuous ECG and hemodynamic monitoring, and avoid in patients with heart failure or conduction disease. Reduce doses and stop if QRS widening or hypotension occurs.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Ex vivo expanded autologous human corneal epithelial cells containing stem cells, Nirmatrelvir / ritonavir. The full list is on the Lidocaine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
