藥物交互作用
Buprenorphine + Orphenadrin
嚴重程度: 嚴重
Buprenorphine and Orphenadrin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both agents depress the central nervous system, so combined use may cause increased drowsiness, dizziness and, in higher exposures, respiratory depression. Opioid labeling warns about concurrent use of CNS depressants.
用白話說明這項交互作用的意義
Buprenorphine and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression from opioid agonism plus sedative and anticholinergic effects of orphenadrine.
處置方式
Use the lowest effective doses for the shortest duration and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and other sedatives.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Orphenadrin 的其他交互作用
Buprenorphine 的其他交互作用
常見問題
Can I take Buprenorphine with Orphenadrin?
MediHelp rates the interaction as major. Buprenorphine and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the central nervous system, so combined use may cause increased drowsiness, dizziness and, in higher exposures, respiratory depression. Opioid labeling warns about concurrent use of CNS depressants.
How serious is the interaction between Buprenorphine and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
