藥物交互作用
Buprenorphine subdermal implant + Eszopiclone
嚴重程度: 嚴重
Buprenorphine subdermal implant and Eszopiclone: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Buprenorphine's ceiling effect on respiratory depression is less protective when other depressants are taken.
用白話說明這項交互作用的意義
Buprenorphine subdermal implant and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression from opioid receptor agonism plus GABA-A potentiation.
處置方式
Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression and counsel the patient and caregivers.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Eszopiclone 的其他交互作用
常見問題
Can I take Buprenorphine subdermal implant with Eszopiclone?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Buprenorphine's ceiling effect on respiratory depression is less protective when other depressants are taken.
How serious is the interaction between Buprenorphine subdermal implant and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression and counsel the patient and caregivers.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
