藥物交互作用
Amobarbital + Eszopiclone
嚴重程度: 嚴重
Amobarbital and Eszopiclone: major interaction.
最後更新
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摘要
Amobarbital can lower eszopiclone levels through enzyme induction, reducing its hypnotic effect. Both drugs also depress the central nervous system, so additive sedation and psychomotor impairment are possible.
用白話說明這項交互作用的意義
Amobarbital and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Eszopiclone belongs to Central Nervous System.
為什麼會發生
Barbiturate induction of CYP3A4 accelerates eszopiclone metabolism, and both agents have additive CNS depressant effects.
處置方式
Avoid combining where possible; if used together, monitor for reduced efficacy and for excess sedation or respiratory depression and counsel against driving.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Eszopiclone 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Eszopiclone?
MediHelp rates the interaction as major. Amobarbital and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital can lower eszopiclone levels through enzyme induction, reducing its hypnotic effect. Both drugs also depress the central nervous system, so additive sedation and psychomotor impairment are possible.
How serious is the interaction between Amobarbital and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if used together, monitor for reduced efficacy and for excess sedation or respiratory depression and counsel against driving.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Eszopiclone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
