藥物交互作用

Bupropion + Selegiline transdermal

嚴重程度: 禁忌併用

Bupropion and Selegiline transdermal: contraindicated interaction.

最後更新 13 十月 2026

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本頁的臨床內容僅提供英文版。

摘要

Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.

Bupropion

用白話說明這項交互作用的意義

Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

證據等級: Moderate

為什麼會發生

Bupropion inhibits dopamine and norepinephrine reuptake while MAO inhibition reduces their breakdown, producing additive catecholaminergic effects.

處置方式

Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Bupropion 與 Selegiline transdermal 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Bupropion with Selegiline transdermal?

MediHelp rates the interaction as contraindicated. Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.

How serious is the interaction between Bupropion and Selegiline transdermal?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.

What other medicines interact with Bupropion?

MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.

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摘要