藥物交互作用
Bupropion + Isocarboxazid
嚴重程度: 禁忌併用
Bupropion and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Isocarboxazid (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
用白話說明這項交互作用的意義
Bupropion and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity
處置方式
Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Bupropion 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Bupropion with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Bupropion and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
How serious is the interaction between Bupropion and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Linezolid, Phenelzine, Rasagiline. The full list is on the Bupropion page.
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