藥物交互作用
Busulfan + Itraconazole
嚴重程度: 嚴重
Busulfan and Itraconazole: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Itraconazole can decrease busulfan clearance and raise its exposure. This may increase myelosuppression and hepatic veno-occlusive disease, which is of particular concern in transplant conditioning.
用白話說明這項交互作用的意義
Busulfan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Busulfan belongs to Oncology; Itraconazole belongs to Anti Fungals.
為什麼會發生
Itraconazole inhibits CYP3A4 and glutathione-related busulfan metabolism, reducing busulfan clearance.
處置方式
Monitor busulfan levels where available and adjust the dose accordingly. Watch blood counts and liver function closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Itraconazole 的其他交互作用
Busulfan 的其他交互作用
常見問題
Can I take Busulfan with Itraconazole?
MediHelp rates the interaction as major. Busulfan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can decrease busulfan clearance and raise its exposure. This may increase myelosuppression and hepatic veno-occlusive disease, which is of particular concern in transplant conditioning.
How serious is the interaction between Busulfan and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor busulfan levels where available and adjust the dose accordingly. Watch blood counts and liver function closely.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
