藥物交互作用
Busulfan + Hydroxyurea
嚴重程度: 嚴重
Busulfan and Hydroxyurea: major interaction.
最後更新
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摘要
Both drugs cause bone marrow suppression, and combined use can produce profound cytopenias. This increases the risk of infection, bleeding and prolonged recovery.
用白話說明這項交互作用的意義
Busulfan and Hydroxyurea can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Busulfan belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
為什麼會發生
Additive myelosuppression from two cytotoxic agents.
處置方式
Monitor complete blood counts frequently and reduce doses or interrupt therapy for severe cytopenias. Follow established protocol dosing when used together.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Hydroxyurea 的其他交互作用
Busulfan 的其他交互作用
常見問題
Can I take Busulfan with Hydroxyurea?
MediHelp rates the interaction as major. Busulfan and Hydroxyurea can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause bone marrow suppression, and combined use can produce profound cytopenias. This increases the risk of infection, bleeding and prolonged recovery.
How serious is the interaction between Busulfan and Hydroxyurea?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or interrupt therapy for severe cytopenias. Follow established protocol dosing when used together.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
