藥物交互作用
Calcium / magnesium / potassium / sodium oxybates + Clonazepam
嚴重程度: 禁忌併用
Calcium / magnesium / potassium / sodium oxybates and Clonazepam: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Oxybates are potent CNS depressants and combining them with benzodiazepines increases the risk of profound sedation, respiratory depression, coma and death. Oxybate labeling advises against concurrent use with sedative hypnotics.
用白話說明這項交互作用的意義
Calcium / magnesium / potassium / sodium oxybates and Clonazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive CNS and respiratory depression via GABA-B agonism from oxybate and GABA-A potentiation from clonazepam.
處置方式
Avoid the combination; replace the benzodiazepine or reconsider the oxybate. If unavoidable, use minimal doses with close monitoring of consciousness and respiration.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clonazepam 的其他交互作用
常見問題
Can I take Calcium / magnesium / potassium / sodium oxybates with Clonazepam?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Clonazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants and combining them with benzodiazepines increases the risk of profound sedation, respiratory depression, coma and death. Oxybate labeling advises against concurrent use with sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Clonazepam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; replace the benzodiazepine or reconsider the oxybate. If unavoidable, use minimal doses with close monitoring of consciousness and respiration.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Clonazepam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
