藥物交互作用
Clonazepam + Sodium oxybate
嚴重程度: 禁忌併用
Clonazepam and Sodium oxybate: contraindicated interaction.
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摘要
Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
用白話說明這項交互作用的意義
Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clonazepam belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
為什麼會發生
Additive CNS and respiratory depression via GABA-B agonism from oxybate and GABA-A potentiation from clonazepam.
處置方式
Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clonazepam 的其他交互作用
Sodium oxybate 的其他交互作用
常見問題
Can I take Clonazepam with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
How serious is the interaction between Clonazepam and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Clonazepam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
