藥物交互作用
Candesartan + Hydrochlorothiazide-lisinopril
嚴重程度: 嚴重
Candesartan and Hydrochlorothiazide-lisinopril: major interaction.
最後更新
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摘要
Combining an ARB with an ACE inhibitor gives dual renin-angiotensin blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit. Hydrochlorothiazide only partly offsets the potassium rise.
用白話說明這項交互作用的意義
Candesartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
為什麼會發生
Dual blockade of the renin-angiotensin-aldosterone system at two points.
處置方式
Avoid combining an ARB with lisinopril except in specialist-supervised situations. If used, monitor potassium and creatinine closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Hydrochlorothiazide-lisinopril 的其他交互作用
- Dofetilide + Hydrochlorothiazide-lisinopril 禁忌併用
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan 禁忌併用
- Amifostine + Hydrochlorothiazide-lisinopril 嚴重
- Amiloride + Hydrochlorothiazide-lisinopril 嚴重
- Benazepril + Hydrochlorothiazide-lisinopril 嚴重
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril 嚴重
Candesartan 的其他交互作用
常見問題
Can I take Candesartan with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Candesartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ARB with an ACE inhibitor gives dual renin-angiotensin blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit. Hydrochlorothiazide only partly offsets the potassium rise.
How serious is the interaction between Candesartan and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining an ARB with lisinopril except in specialist-supervised situations. If used, monitor potassium and creatinine closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
