藥物交互作用
Candesartan-hydrochlorothiazide + Chlorthalidone
嚴重程度: 嚴重
Candesartan-hydrochlorothiazide and Chlorthalidone: major interaction.
最後更新
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摘要
Chlorthalidone and hydrochlorothiazide are both thiazide-type diuretics, so using them together duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia.
用白話說明這項交互作用的意義
Candesartan-hydrochlorothiazide and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
為什麼會發生
Therapeutic duplication with additive inhibition of the distal tubule sodium-chloride cotransporter.
處置方式
Avoid concurrent use and keep to a single thiazide-type agent. If both have been used, check electrolytes and renal function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Candesartan-hydrochlorothiazide 的其他交互作用
Chlorthalidone 的其他交互作用
常見問題
Can I take Candesartan-hydrochlorothiazide with Chlorthalidone?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorthalidone and hydrochlorothiazide are both thiazide-type diuretics, so using them together duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorthalidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep to a single thiazide-type agent. If both have been used, check electrolytes and renal function.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
