藥物交互作用
Chlorthalidone + Eprosartan-hydrochlorothiazide
嚴重程度: 嚴重
Chlorthalidone and Eprosartan-hydrochlorothiazide: major interaction.
最後更新
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摘要
Chlorthalidone is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and hyperuricemia without a clear advantage.
用白話說明這項交互作用的意義
Chlorthalidone and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorthalidone belongs to Cardiovascular; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
為什麼會發生
Duplicate inhibition of the sodium-chloride cotransporter in the distal convoluted tubule, causing additive natriuresis and potassium loss.
處置方式
Avoid using two thiazide-type diuretics together and keep a single agent. If used deliberately, monitor sodium, potassium and renal function closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Eprosartan-hydrochlorothiazide 的其他交互作用
Chlorthalidone 的其他交互作用
常見問題
Can I take Chlorthalidone with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Chlorthalidone and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorthalidone is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and hyperuricemia without a clear advantage.
How serious is the interaction between Chlorthalidone and Eprosartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together and keep a single agent. If used deliberately, monitor sodium, potassium and renal function closely.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
