藥物交互作用
Atenolol-chlorthalidone + Chlorthalidone
嚴重程度: 嚴重
Atenolol-chlorthalidone and Chlorthalidone: major interaction.
最後更新
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摘要
The combination product already contains chlorthalidone, so adding more duplicates diuretic therapy. This increases the risk of volume depletion, hypotension, hypokalemia, hyponatremia and hyperuricemia.
用白話說明這項交互作用的意義
Atenolol-chlorthalidone and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
為什麼會發生
Therapeutic duplication of thiazide-like diuretic activity causing additive natriuresis and potassium loss.
處置方式
Avoid concurrent use; prescribe a single chlorthalidone source and monitor electrolytes and blood pressure if doses are adjusted.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atenolol-chlorthalidone 的其他交互作用
Chlorthalidone 的其他交互作用
常見問題
Can I take Atenolol-chlorthalidone with Chlorthalidone?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination product already contains chlorthalidone, so adding more duplicates diuretic therapy. This increases the risk of volume depletion, hypotension, hypokalemia, hyponatremia and hyperuricemia.
How serious is the interaction between Atenolol-chlorthalidone and Chlorthalidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; prescribe a single chlorthalidone source and monitor electrolytes and blood pressure if doses are adjusted.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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