藥物交互作用
Cefadroxil + Kanamycin
嚴重程度: 中度
Cefadroxil and Kanamycin: moderate interaction.
最後更新
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摘要
Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have occasionally been reported to add to renal injury when combined with them. Cefadroxil has little intrinsic nephrotoxicity, so the added risk is modest but matters in patients with reduced renal function. Both drugs are renally eliminated, so impairment raises exposure to each.
用白話說明這項交互作用的意義
Cefadroxil and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive renal tubular injury, with reduced renal clearance of both drugs when kidney function declines.
處置方式
Monitor serum creatinine and aminoglycoside levels, and adjust doses to renal function. Ensure hydration and watch for hearing or balance changes.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefadroxil 的其他交互作用
常見問題
Can I take Cefadroxil with Kanamycin?
MediHelp rates the interaction as moderate. Cefadroxil and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have occasionally been reported to add to renal injury when combined with them. Cefadroxil has little intrinsic nephrotoxicity, so the added risk is modest but matters in patients with reduced renal function. Both drugs are renally eliminated, so impairment raises exposure to each.
How serious is the interaction between Cefadroxil and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and aminoglycoside levels, and adjust doses to renal function. Ensure hydration and watch for hearing or balance changes.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
