藥物交互作用
Cefadroxil + Mycophenolate
嚴重程度: 中度
Cefadroxil and Mycophenolate: moderate interaction.
最後更新
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摘要
Some antibiotics, including cephalosporins, have been associated with lower mycophenolic acid exposure, probably by reducing gut bacteria that deconjugate the glucuronide and allow its reabsorption. The legacy renal competition explanation is not well supported. Reduced exposure could weaken immunosuppression.
用白話說明這項交互作用的意義
Cefadroxil and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Probable reduction of enterohepatic recirculation of mycophenolic acid glucuronide due to gut flora changes.
處置方式
Watch for signs of graft rejection or reduced immunosuppression during and after the antibiotic course. Consider mycophenolic acid level monitoring where available.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefadroxil 的其他交互作用
常見問題
Can I take Cefadroxil with Mycophenolate?
MediHelp rates the interaction as moderate. Cefadroxil and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Some antibiotics, including cephalosporins, have been associated with lower mycophenolic acid exposure, probably by reducing gut bacteria that deconjugate the glucuronide and allow its reabsorption. The legacy renal competition explanation is not well supported. Reduced exposure could weaken immunosuppression.
How serious is the interaction between Cefadroxil and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of graft rejection or reduced immunosuppression during and after the antibiotic course. Consider mycophenolic acid level monitoring where available.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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