藥物交互作用
Cefadroxil + Neomycin po
嚴重程度: 中度
Cefadroxil and Neomycin po: moderate interaction.
最後更新
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摘要
Oral neomycin is poorly absorbed, but systemic absorption can occur with impaired gut mucosa or renal impairment, and it is nephrotoxic and ototoxic. Combined with cephalosporins, additive kidney injury has been suggested. Cefadroxil itself is only weakly nephrotoxic.
用白話說明這項交互作用的意義
Cefadroxil and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Potential additive nephrotoxicity from systemically absorbed neomycin with reduced renal clearance of both drugs.
處置方式
Monitor renal function, especially with renal impairment or prolonged neomycin use. Adjust cefadroxil dose to creatinine clearance.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefadroxil 的其他交互作用
常見問題
Can I take Cefadroxil with Neomycin po?
MediHelp rates the interaction as moderate. Cefadroxil and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin is poorly absorbed, but systemic absorption can occur with impaired gut mucosa or renal impairment, and it is nephrotoxic and ototoxic. Combined with cephalosporins, additive kidney injury has been suggested. Cefadroxil itself is only weakly nephrotoxic.
How serious is the interaction between Cefadroxil and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, especially with renal impairment or prolonged neomycin use. Adjust cefadroxil dose to creatinine clearance.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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