藥物交互作用
Cefoxitin + Kanamycin
嚴重程度: 中度
Cefoxitin and Kanamycin: moderate interaction.
最後更新
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摘要
Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
用白話說明這項交互作用的意義
Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive nephrotoxic potential, with aminoglycoside-related tubular injury and ototoxicity possibly aggravated by reduced renal clearance.
處置方式
Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefoxitin 的其他交互作用
常見問題
Can I take Cefoxitin with Kanamycin?
MediHelp rates the interaction as moderate. Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
How serious is the interaction between Cefoxitin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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