藥物交互作用
Aztreonam + Cefoxitin
嚴重程度: 中度
Aztreonam and Cefoxitin: moderate interaction.
最後更新
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摘要
Cefoxitin can induce chromosomal beta-lactamases in some Gram-negative bacteria such as Enterobacter and Pseudomonas, which may reduce aztreonam activity. This is an in vitro antagonism, and its clinical relevance is uncertain.
用白話說明這項交互作用的意義
Aztreonam and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aztreonam belongs to Anti Bacterial; Cefoxitin belongs to Anti Bacterial.
為什麼會發生
Cefoxitin induces inducible beta-lactamase production in some Gram-negative bacteria, which can hydrolyze aztreonam.
處置方式
Avoid pairing the two when treating organisms known to produce inducible beta-lactamases. Guide therapy by culture and susceptibility results.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefoxitin 的其他交互作用
Aztreonam 的其他交互作用
常見問題
Can I take Aztreonam with Cefoxitin?
MediHelp rates the interaction as moderate. Aztreonam and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefoxitin can induce chromosomal beta-lactamases in some Gram-negative bacteria such as Enterobacter and Pseudomonas, which may reduce aztreonam activity. This is an in vitro antagonism, and its clinical relevance is uncertain.
How serious is the interaction between Aztreonam and Cefoxitin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pairing the two when treating organisms known to produce inducible beta-lactamases. Guide therapy by culture and susceptibility results.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Bcg vaccine live, Chloramphenicol. The full list is on the Cefoxitin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
