藥物交互作用
Chenodeoxycholic acid + Cyclosporin
嚴重程度: 嚴重
Chenodeoxycholic acid and Cyclosporin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Ciclosporin may inhibit CYP27A1 and reduce bile acid synthesis, which may blunt the effect of chenodeoxycholic acid in conditions like cerebrotendinous xanthomatosis. Disease control could worsen.
用白話說明這項交互作用的意義
Chenodeoxycholic acid and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chenodeoxycholic acid belongs to Gastrointestinal Tract; Cyclosporin belongs to Miscellaneous.
為什麼會發生
Inhibition of CYP27A1 by ciclosporin reduces bile acid synthesis and alters pharmacodynamic response.
處置方式
Avoid if possible; otherwise monitor serum bile alcohols and adjust the chenodeoxycholic acid dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chenodeoxycholic acid 的其他交互作用
Cyclosporin 的其他交互作用
常見問題
Can I take Chenodeoxycholic acid with Cyclosporin?
MediHelp rates the interaction as major. Chenodeoxycholic acid and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ciclosporin may inhibit CYP27A1 and reduce bile acid synthesis, which may blunt the effect of chenodeoxycholic acid in conditions like cerebrotendinous xanthomatosis. Disease control could worsen.
How serious is the interaction between Chenodeoxycholic acid and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor serum bile alcohols and adjust the chenodeoxycholic acid dose.
What other medicines interact with Chenodeoxycholic acid?
MediHelp also lists interactions of Chenodeoxycholic acid with, for example, Sirolimus, Aluminum hydroxide, Colestipol. The full list is on the Chenodeoxycholic acid page.
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