藥物交互作用
Cimetidine + Clozapine
嚴重程度: 嚴重
Cimetidine and Clozapine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cimetidine can increase clozapine levels, with reports of increased sedation, seizures and other toxicity. Clozapine has a narrow therapeutic window, so exposure changes matter.
用白話說明這項交互作用的意義
Cimetidine and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Clozapine belongs to Central Nervous System.
為什麼會發生
Cimetidine inhibits CYP1A2 and CYP3A4 metabolism of clozapine.
處置方式
Prefer famotidine or another acid suppressant; if cimetidine is used, monitor clozapine levels and for sedation, hypotension and seizures, and reduce the dose as required.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cimetidine 的其他交互作用
Clozapine 的其他交互作用
常見問題
Can I take Cimetidine with Clozapine?
MediHelp rates the interaction as major. Cimetidine and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine can increase clozapine levels, with reports of increased sedation, seizures and other toxicity. Clozapine has a narrow therapeutic window, so exposure changes matter.
How serious is the interaction between Cimetidine and Clozapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer famotidine or another acid suppressant; if cimetidine is used, monitor clozapine levels and for sedation, hypotension and seizures, and reduce the dose as required.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
