藥物交互作用
Cimetidine + Fezolinetant
嚴重程度: 禁忌併用
Cimetidine and Fezolinetant: contraindicated interaction.
最後更新
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摘要
Cimetidine inhibits CYP1A2 and can increase fezolinetant exposure, raising the risk of adverse effects including liver enzyme elevation. Fezolinetant labeling contraindicates concomitant CYP1A2 inhibitors.
用白話說明這項交互作用的意義
Cimetidine and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cimetidine belongs to Gastrointestinal Tract; Fezolinetant belongs to Endocrine.
為什麼會發生
Inhibition of CYP1A2-mediated metabolism of fezolinetant increases its plasma concentrations.
處置方式
Do not combine; use famotidine or another non-CYP1A2-inhibiting acid suppressant. Monitor liver tests if exposure occurs.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cimetidine 的其他交互作用
Fezolinetant 的其他交互作用
常見問題
Can I take Cimetidine with Fezolinetant?
MediHelp rates the interaction as contraindicated. Cimetidine and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cimetidine inhibits CYP1A2 and can increase fezolinetant exposure, raising the risk of adverse effects including liver enzyme elevation. Fezolinetant labeling contraindicates concomitant CYP1A2 inhibitors.
How serious is the interaction between Cimetidine and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use famotidine or another non-CYP1A2-inhibiting acid suppressant. Monitor liver tests if exposure occurs.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Alfentanil, Atazanavir. The full list is on the Cimetidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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