藥物交互作用
Carmustine + Cimetidine
嚴重程度: 嚴重
Carmustine and Cimetidine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cimetidine has been reported to increase carmustine-related bone marrow suppression. This may produce deeper or more prolonged leukopenia and thrombocytopenia.
用白話說明這項交互作用的意義
Carmustine and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carmustine belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
為什麼會發生
Cimetidine may reduce hepatic metabolism of carmustine and possibly adds to marrow suppression; the mechanism is not fully established.
處置方式
Avoid the combination where possible and use famotidine or another acid suppressant instead. If given together, monitor complete blood counts closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cimetidine 的其他交互作用
Carmustine 的其他交互作用
常見問題
Can I take Carmustine with Cimetidine?
MediHelp rates the interaction as major. Carmustine and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine has been reported to increase carmustine-related bone marrow suppression. This may produce deeper or more prolonged leukopenia and thrombocytopenia.
How serious is the interaction between Carmustine and Cimetidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use famotidine or another acid suppressant instead. If given together, monitor complete blood counts closely.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
